UNDER DEVELOPMENT
MAJOR ADVANCES IN CANCER IMMUNOTHERAPY
Disclosure: Many publications were reviewed and found to be of strong merit. We chose to list only a few of these publications here based on independent review by the Beatty Laboratory and relevance to our work.
2019
SEP 2019 Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019 Sep;21(9):1113-1126.
FEB 2019 A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma. Nat Med. 019 Feb 25. doi: 10.1038/s41591-019-0357-y. [Epub ahead of print]
FEB 2019 Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma. Cell. 2019 Feb 25. doi: 10.1038/s41591-019-0357-y. [Epub ahead of print]
JAN 2019 Intratumoral Tcf1+PD-1+CD8+ T cells with Stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy. Immunity. 2019 Jan 15;50(1):195-211.e10.
JAN 2019 Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells. Immunity. 2019 Jan 15;50(1):181-194.e6.
2018
DEC 2018 Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. Cell. 2018 Dec 13;175(7):1731-1743.e13.
DEC 2018 NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. Cell. 2018 Dec 13;175(7):1744-1755.e15.
DEC 2018 Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy. JCI Insight. 2018 Dec 6;3(23). pii: 124507.
DEC 2018 Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018 Dec 18;49(6):1148-1161.e7.
OCT, 2018 Evolution of Metastases in Space and Time under Immune Selection. Cell. 2018 Oct 18;175(3):751-765.e16.
APR, 2018 Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. Immunity. 2018 Apr 17;48(4):773-786
UNDER DEVELOPMENT
2017
Nov 2017 Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. Cell. 2017 Nov 30;171(6):1301-1315.e14.
2016
Oct 2016 L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016 Oct 20;167(3):829-842.
UNDER DEVELOPMENT
2015
2014
May 2014 Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci Transl Med. 2014 May 21;6(237):237ra67.
UNDER DEVELOPMENT
2013
2012
May 2012 S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell. 2012 May 15;21(5):642-54.
UNDER DEVELOPMENT
