Research Specialist A

Description: The candidate will act as a histology research assistant and will work on projects analyzing the immune contexture of mouse and human cancer tissues using multiplex imaging and analysis tools. The research assistant will collaborate with the laboratory team on various projects. The candidate will be required to work independently, collaboratively, possessing strong writing, presentation and analytical skills. He/She will be responsible for 1) tissue sectioning, 2) assisting in the operation of automated immunostaining procedures, 3) slide scanning and image acquisition, 4) management of image files, 5) basic image analysis, 6) development of novel of image analytical tools and procedures, and 7) development of presentations and reports displaying results of image analyses. The candidate will also be involved as necessary in the analysis of multidimensional flow cytometry and transcriptome analyses. The successful candidate will have a strong work ethic/motivation, meticulous organizational skills, solid computational skills, and strong social/communication skills.

Qualifications: Applicant should have a Bachelor’s degree (a degree in the biological sciences is preferred, but not required). Experience with general techniques in cellular biology, histology, and flow cytometry is preferred. Outstanding computer and communication skills are preferred. Meticulous record keeping skills are essential for this position. A minimum of two-year commitment is preferred.


Post-doctoral Position (early discovery)

Description: The candidate will act as a full-time post-doctoral researcher to study mechanisms of response and resistance directed by myeloid cells in cancer. Inflammation is a key determinant of cancer biology and resistance to cytotoxic- and immune-based therapies. We have previously shown that a subset of myeloid cells can be redirected with anti-tumor potential to enhance the efficacy of chemotherapy. We have also found that a distinct subset of myeloid cells regulates T cell immunosurveillance in cancer. In this position, the candidate will study the determinants that regulate the capacity of myeloid cells to suppress cancer growth and investigate strategies to reverse myeloid suppression of T cell priming. The candidate will have the opportunity to undertake and learn many skills including: 1) the application of novel animal models of cancer and 2) multidimensional analyses of T cell and myeloid cell biology using transcriptional, flow cytometry, and multiplex IHC/IF techniques. The candidate will learn fundamentals of immunobiology in cancer, state-of-the-art approaches to understanding immune mechanisms of resistance and response, and key principals in applying basic science research to inform clinical investigation.

Qualifications: Applicant should have a MD, PhD or both with a background in immunology, cancer biology, or cellular biology. Experience with general techniques in cellular biology, histology, flow cytometry, and the conduct of animal experiments (including surgical procedures) is preferred. Outstanding writing/communication skills  and strong motivation are required. Meticulous record keeping skills are essential for this position. The applicant should have a solid publication record and will be expected to apply for funding during the course of their training.


Post-doctoral Position (translational discovery)

Description: The candidate will act as a full-time post-doctoral researcher to study the "immune connectome" in tumors. Within the tumor microenvironment, immune cells engage in dynamic and multiple interactions with many cells which determine their ultimate fate. Tumors are remarkably heterogeneous and establish multiple unique communities. The biology and relevance of these spatially distinct environments, though, is poorly understood. In addition, little is known about the capacity to shift the "immunological state" of these communities to favor productive immune surveillance and to suppress tumor growth and metastasis. This knowledge would have remarkable implications for designing novel treatment paradigms for improving therapeutic outcomes. We have developed many of the multidimensional and spatial analysis tools necessary to interrogate this biology. In this position, the candidate will study this biology using human tissue specimens and tissues derived from animal models. Studies will involve the use of multi-dimensional flow cytometry, CyTOF, RNA sequencing, multi-plex IHC/IF, and image analysis software. The candidate will have the opportunity to learn cutting-edge skills and knowledge in the spatial biology of  tumors. The candidate will learn fundamentals of immunobiology in cancer, state-of-the-art approaches to understanding immune mechanisms of resistance and response, and key principals in applying basic science research to inform clinical investigation.

Qualifications: Applicant should have a MD, PhD or both with a background in immunology, cancer biology, or cellular biology. Experience with general techniques in cellular biology, histology, flow cytometry, and the conduct of animal experiments (including surgical procedures) is preferred. Outstanding writing/communication skills  and strong motivation are required. Meticulous record keeping skills are essential for this position. The applicant should have a solid publication record and will be expected to apply for funding during the course of their training.

PhD and MD/PhD Graduate students interested in positions to study basic mechanisms of immunobiology (involving myeloid cells and T cells) in cancer are welcome to apply for positions in the laboratory at any time. Qualifications: all students will be expected to write for student fellowship applications.